A novel biodegradable injectable chitosan hydrogel for overcoming postoperative trauma and combating multiple tumors

Wound bacterial infections and tumor recurrence are the main reasons for poor prognosis after primary resection. Here, we fabricated a novel therapeutic nanocomposite using chitosan (CS) hydrogel combined with black phosphate nanosheets (BPNSs) in situ grown copper nanoparticles (CuNPs). The obtained ([email protected]@CuNPs), possessing remarkable temperature-sensitive spongy-like state, offered 24.98 % blood clotting index. released [email protected] could produce reactive oxygen species (ROS) to kill infected invasive bacteria (98.1 %) inhibit local residual cell regeneration (11.3 %). Moreover, by coupling photothermal properties of BPNSs, showed 19.6 penetration rate cross barrier (BTB) treating brain tumors. platform was further aPD-L1-based immunotherapy employ its synergetic effect prevention vivo studies that biodegradable hold great potential as strategy improving postoperative therapy multi-tumor treatments.